Coffee Has Many Health Benefits

Coffee seems to have broad and significant benefits. Much Recent Research Has Coffee Sounding Like a Wonder-Drugcoffee-notes

As a coffee addict, this is welcome news. A variety of epidemiological studies show coffee having cardio benefits, lowerings some cancer risks, as well as the risk of adult onset diabetes, Alzheimers, and all cause mortality.

Marriage, Polygamy, and Heart Disease

Marriage Appears to Reduce Heart Disease Among Men. Unless They Have Multiple Wives.poly

It is widely believed that married people are healthier and live longer. This is true, but not for the reasons you might think.

For instance, perceived marital happiness, satisfaction with the marriage, and frequency of disagreements were not related to either heart health, or death from all causes. This seems odd. One would surely expect some pleasant, cheerful couple to outlive one that squabbled constantly.

Monoclonal Antibodies Should Be The Last Resort

Monoclonal antibodies are the latest hot drug. They are very expensive to produce, usually offer only limited benefit if any, and often have unexpected consequences.

Monoclonal antibodies are an attempt to engage the adaptive immune system in the fight against some disease. The adaptive immune system marks a pathogen with antibodies. Antibodies are small “Y” shaped proteins manufactured by B-type white blood cells. There are literally millions of different ones on patrol, each designated to recognize a different pathogen—bacteria, virus, or other foreign material. The antibody usually disables it and marks it for destruction.

Pathogenic Trickery—How Germs Thwart The Immune System

The body has an elaborate defense system against bacteria and viruses. The only ones that are successful are those that have managed to defeat it. They use every trick in the book and then some.pathogen-trickery

We have two immune systems, both of which are very effective against bacterial and viral invaders. The older one, the innate immune system,  is found in all animals from worms on up. The newer one, the adaptive immune system, is a vertebrate only feature. The innate immune system cells, called phagocytes, are fast acting and on the spot. It’s a little clumsy at recognizing bacteria, but will try to engulf or poison it if it does.

Rosuvastatin (Crestor) Has Little Overall Benefit And Has Many Problems

Rosuvastatin lowers cholesterol more than all the other statins, and because of this, it was hailed as a breakthrough drug. With a huge advertising budget behind it, it became a blockbuster—the top selling statin. But it has a checkered past, and as time goes by, more and more problems seem to be turning up, and less and less benefit is evident.crestor-pills-money

Rosuvastatin’s presumed benefit was its extreme lowering of LDL cholesterol, like from 120 to 55. A lot. A decade ago, it was widely believed that cholesterol was some sort of toxin, and so the less of it the better. This thinking has been substantially revised, for reasons we will get to in a moment.

Octopuses—An Alternate Evolutionary Track?

Apparently vertebrates diverged from crustaceans about the same time as octopuses. We have evolved a complex body with distributed functions, a closed circulation system, and high intelligence. So have octopuses.Octopus-Multitask

Crustaceans have an ectoskeleton (hard shell) and no circulatory system. They are also universally dumber than a stone. At some point, the exoskeleton was jettisoned. We vertebrates went on to evolve our internal one, but the octopuses decided that no skeleton might work just as well.